Tuesday, August 4, 2020

GE2020: Middle-aged voters, not youths, accounted for national vote swing against PAP, says Lawrence Wong

By NG JUN SEN

19 July, 2020

  • Ruling party lost votes from middle-aged voters in the sandwich class
  • PAP did not do well in its digital campaign despite putting out a lot of content
  • Party will review its style, conduct of campaign including how it goes about highlighting falsehoods 

SINGAPORE — Suggestions that younger voters across the board had abandoned the People’s Action Party (PAP) in the recent General Election (GE) are untrue, PAP’s Lawrence Wong said on Saturday (July 18).

A preliminary review on the party’s performance has shown that the more likely swing came from “sandwiched” middle-class voters who have been affected by the economic effects of the Covid-19 pandemic, he added.

Swing votes also came from those who were swayed by the opposition’s messaging that there was a real threat of an opposition wipeout in the election.

Monday, August 3, 2020

Commentary: Malay political unity in Malaysia is but a myth

What’s behind Prime Minister Mahathir Mohamad’s call for Malay unity and for Members of Parliament from other parties to join Bersatu? James Chin dives into the issues.
By James Chin

08 Jul 2019


LONDON: Last week, out of the blue, Malaysian Prime Minister Mahathir Mohamad invited all Malay parties including UMNO to join Bersatu in an effort to unite the Malays.

“If we are split, we become weak. United we stand, divided we fall,” he said. "(But) we find that there are people forming new parties ... how to win (the election)?”

The invitation was immediately dismissed by most senior leaders in UMNO. Even PAS, the Islamic Party, said they were not interested.

UMNO even gave a cutting reply - that UMNO and PAS were the “real” Malay parties in Malaysia as Bersatu got less than 30 per cent of the Malay vote in last May’s general elections.

Commentary: The great pity that was Malaysia’s short-lived Pakatan Harapan coalition

The ideological schisms between parties, coupled with perceptions that Malay rights had been chipped at and pressing economic concerns left unaddressed, ultimately led to the PH’s downfall, says Wan Saiful Wan Jan.


By Wan Saiful Wan Jan

03 Aug 2020

SINGAPORE: Malaysia’s Pakatan Harapan (PH) government lasted less than two years.

After winning the 14th general election (GE14) on that historic May 9, 2018 to great fanfare, it crashed on Feb 24 this year following the sudden resignation of Prime Minister Mahathir Mohamad and the departure of Bersatu from the Pakatan Harapan (PH) coalition.

Many were surprised by this collapse, but a closer look at the nature of PH and how they behaved in government will show that the PH administration were riddled with problems.


Sunday, August 2, 2020

Bio-printing, organoids,

A possible weapon against the pandemic: Printing human tissue


01 August, 2020

NEW YORK — As shortages of personal protective equipment persist during the coronavirus pandemic, 3D printing has helped to alleviate some of the gaps. But Dr Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine, and his team are using the process in a more innovative way: creating tiny replicas of human organs — some as small as a pinhead — to test drugs to fight Covid-19.

The team is constructing miniature lungs and colons — two organs particularly affected by the coronavirus — then sending them overnight by courier for testing at a biosafety lab at George Mason University in Fairfax, Virginia. While they initially created some of the organoids by hand using a pipette, they are beginning to print these at scale for research as the pandemic continues to surge.

In the last few years, Dr Atala’s institute had already printed these tiny clusters of cells to test drug efficacy against bacteria and infectious diseases like the Zika virus, “but we never thought we’d be considering this for a pandemic”, he said. His team has the ability to print “thousands an hour”, he said from his lab in Winston-Salem, North Carolina.

The process of constructing human tissue this way is a form of bioprinting. While its use in humans is still years away, researchers are honing the methods to test drugs and, eventually, to create skin and full-size organs for transplanting. Researchers are making strides in printing skin, critical for burn victims; managing diseases like diabetes in which wound healing is difficult; and for the testing of cosmetics without harming animals, or, of course, humans.

“Even to us it sometimes seems like science fiction,” said Dr Akhilesh Gaharwar, who directs a cross-disciplinary lab in the biomedical engineering department at Texas A&M University that focuses on bioprinting and other approaches to regenerative medicine.

Bioprinting’s importance for pharmaceutical analysis is paramount now, not only for potential Covid-19 treatments but also for testing treatments for cancer and other diseases. Dr Atala says that the organoids allow researchers to analyse a drug’s effect on an organ “without the noise” of an individual’s metabolism.

He cited Rezulin, a popular diabetes drug recalled in 2000 after there was evidence of liver failure. His lab tested an archived version of the drug, and Dr Atala said that within two weeks, the liver toxicity became apparent. What accounts for the difference? An organoid replicates an organ in its purest form and offers data points that might not occur in clinical trials, he said, adding that the testing is additive to, rather than in lieu of, clinical trials.

Testing on bioprinted skin or other miniature organs also can more readily determine which drugs that work in animals like rats might not perform well in people.

“The 3D models can circumvent animal testing and make the pathway stronger from the lab to the clinic,” Dr Gaharwar said. That has importance for consumer goods as well as pharmaceuticals; since 2013, the European Union, for example, has prohibited cosmetics companies from testing products on animals.

The foundation for a printed organ is known as a scaffold, made of biodegradable materials. To provide nutrition for the organoid, microscopic channels only 50 microns in diameter — roughly half the size of a human hair — are included in the scaffold. Once completed, the “bioink”, a liquid combination of cells and hydrogel that turns into gelatin, is then printed onto the scaffold “like a layer cake”, Dr Atala said.

Another important part of the process is constructing blood vessels as part of the printing. Dr Pankaj Karande, an assistant professor of chemical and biological engineering at Rensselaer Polytechnic Institute, has been experimenting with skin printing since 2014 and recently had success in this step.

Using a cell known as a fibroblast, which helps with growth, along with collagen, as a scaffold, researchers at the institute printed the epidermis and dermis, the first two layers of skin. (The hypodermis is the third layer.) “It turns out the skin cells don’t mind being sheared,” Dr Karande said, and they could ultimately survive.

But their work hit a snag: Without incorporating blood vessels, the skin eventually sloughs off. Collaborating with Yale University’s Jordan Pober and W. Mark Saltzman, they eventually succeeded in constructing all three layers of human skin as well as vasculature, or blood vessels, which Dr Karande said was essential to the skin’s surviving after it had been grafted.

The three began experimenting with integrating human endothelial cells, which line blood vessels, and human pericyte cells, which surround the endothelial cells, into the skin as it was printed. Eventually, after much trial and error, they were able to integrate the blood vessels with the skin and found that connections were formed between new and existing blood vessels.

While the work is preliminary — tested in mice — Dr Karande said he was hopeful that the success in printing integrated skin and vasculature would set the stage for successful grafting in humans eventually.

The research, according to Dr Karande, is painstaking and involves a lot of trial and error. “We have Plan A, which we often know won’t work, and then we go down the list. We can often write about what works in five pages but have 5,000 pages of what didn’t work,” he added.

Dr Gaharwar’s lab is also investigating whether human bone tissue can be printed for eventual transplantation. His hope, he says, is that in the future, patient radiographic scans can be translated into the exact shape needed for implantation, especially important in repairing craniofacial defects in which the curvature needed can be difficult to re-create.

Like Dr Gaharwar, Dr Karande says that personalisation is important. He says that his work has already shown that skin can be fabricated to match an individual’s colour. And, because the skin is also critical in regulating body temperature, he is also working to engineer sweat glands into the skin, along with hair follicles.

“When we graft, we want to be able to re-create the full functionality of the skin,” Dr Karande said. And by using the cells from a patient, rather than a donor, the risk of rejection is minimised or eliminated altogether.

Not surprisingly, researchers are also exploring the collection of data from testing. The team at Wake Forest is partnering with technology company Oracle to capture the data from the organoids and analyse it with artificial intelligence. The project, known generally as the body-on-a-chip system, involves printing living tissue on a microchip to allow drugs to be studied for toxicity and efficacy even before clinical trials begin. The chips can be the size of a nickel or quarter, which is big enough to hold 10 to 12 miniature organs.

“We work a lot with researchers, pharmaceutical companies and biotech companies, and we are trying to seed advances as quickly as possible, analyse data and develop new drugs,” said Ms Rebecca Laborde, master principal scientist in Oracle’s health sciences division. “This is the most exciting project I’ve worked on in a long time.” 

THE NEW YORK TIMES



Researchers in Singapore grow ‘mini kidneys’ in lab, paving way for potential kidney disease therapies

By Justin Ong

20 August, 2019

SINGAPORE — Patients with kidney disease could eventually benefit from “mini kidneys” grown in a laboratory by an international team of researchers led by Nanyang Technological University (NTU), the university said on Tuesday (Aug 20).

These mini kidneys — derived from the patient’s cells — could be used to test certain drugs and help researchers better ascertain which treatment plans a patient with kidney disease needs, NTU said in a media statement.

Tailoring treatment to an individual patient is important as genetic errors that cause kidney failure differ from patient to patient, NTU said.

Using the mini kidneys to test the therapeutic effects of drugs removes the need to carry out drug screening on the patients themselves, it added.

The researchers grew the kidney “organoids” — a miniature version of an organ — from skin cells of patients with a common inherited cause of kidney failure known as polycystic kidney disease, a genetic disorder where multiple cysts develop within the kidney. The mini kidneys measured 1mm to 2mm in diameter.

The cells were grown outside the body in a laboratory and were “reprogrammed” to obtain pluripotent — or self replicating — stem cells, which, under the right conditions, can develop into the mini kidneys, which are similar to human foetal kidneys.

In growing the mini kidneys from the induced stem cells, the research team said it has "paved the way for tailoring treatment plans specific to each patient, which could be extended to a range of kidney diseases’’.

NTU Singapore Assistant Professor Xia Yun, who led the research, said: “Our kidney organoids, grown from the cells of a patient with inherited polycystic kidney disease, have allowed us to find out which drugs will be most effective for this specific patient.”

Dr Xia, who is from the NTU Lee Kong Chian School of Medicine (LKC Medicine), added that this approach could be extended to study many other types of kidney disease, such as diabetic nephropathy — kidney damage that results from having diabetes.

Professor Juan Carlos Izpisua Belmonte, a stem cell scientist and an international collaborator on this study, said: “We are still quite far away from using these kidney organoids for replacement therapy.” But the research represents “a small step closer to this ultimate goal”, he noted. 

Prof Belmonte is based at the Salk Institute for Biological Studies in San Diego, California.

NEW INSIGHTS INTO KIDNEY DEVELOPMENT

While the origin of kidney blood vessel networks is not fully known, the examination of cells within a kidney organoid has led Dr Xia’s team to discover a new source of stem cells — called nephrons — that contribute to making these blood vessel networks.

NTU LKC Medicine Assistant Professor Foo Jia Nee said that these nephrons can be better used to understand the kidney’s development from birth, where being born with higher nephrons appears to “provide some degree of protection” against hypertension and kidney failure later in life.

Dr Xia added: “A thorough understanding of human embryonic kidney development may help us develop ways to promote a high birth nephron number for foetuses as they develop during pregnancy.”

The research was published in the July edition of Cell Stem Cell, a United States-based scientific journal.

Friday, July 24, 2020

GE2020 commentary: Assessing the voters’ message to PAP (and other parties)

By Eugene K B Tan

14 July, 2020


Despite the “crisis of a generation”, the 2020 general election results point to a considered flight from the status quo, rather than a flight to safety.

Singaporean voters, through their 2.54 million ballots cast, sent a nuanced message to all political parties and election candidates. It was a renewed, urgent expression of a vote for change, more so than in the 2011 election.

For the ruling People’s Action Party (PAP), winning 83 out of 93 seats with a popular vote share of 61.24 per cent — while indicative of a “clear mandate” — fell short of the strong mandate it had sought. In losing an unprecedented second group representation constituency (GRC), it also lost three political office-holders in the process.

Many GRCs, including those helmed by the PAP fourth-generation (4G) ministers, also saw the ground shift significantly against them.

This raises questions whether the next generation leadership has truly earned the trust and confidence of Singaporeans. This could not come at a worse time for leadership succession.

Singapore’s economic slump may have bottomed out but job losses, wage cuts likely to continue: Economists

By Janice Lim

15 July, 2020

Singapore’s economy shrank 41.2 per cent in the second quarter compared with the first as the nation went into recession

Economists said that job losses and wage cuts are set to continue

The economic contraction in the second quarter is the most severe since the country's independence


SINGAPORE — The worst of Singapore’s economic contraction is probably over, but more job losses and wage cuts are to be expected, especially in the later part of 2020, economists said on Tuesday (July 14).

Crises

From a Washington Post newsletter:
A reporter approached Sen. Mitt Romney in the Capitol on Wednesday afternoon to ask: “Do you have confidence in the president’s handling of this crisis right now?”
“Which? There are so many crises going on,” replied Romney (R-Utah). “I’m not sure which.”
The 2012 GOP presidential nominee was not trying to be flip and lamented President Trump’s response to the novel coronavirus when the reporter clarified. But our nation faces cascading crises:
the worst civil unrest since 1968, the worst economic upheaval since 1933 and the worst public health emergency since 1918. This morning’s jobs report shows another 1.4 million workers filed for unemployment benefits last week, the 18th straight week that more than a million Americans have filed claims.
Other ongoing crises get less attention because of the contagion, but that does not mean they have been solved.
There is an opioid crisis causing deaths of despair, the climate crisis that imperils the future of the planet, a looming sovereign debt crisis that most political leaders seem nonchalant about, rising great-power conflict with China, including a new space race, and fresh complications overnight in Afghanistan as America struggles to exit her longest war.

[And of course the biggest crisis is that there is an idiot in the White House.]