07 August, 2018
NEW YORK — The gold standard of medical research, the randomised controlled trial, has been taking a bit of a beating lately.
An entire issue of the journal Social Science and Medicine was recently devoted to it, with many articles pointing to shortcomings. Others have argued that randomised controlled trials often can't address the questions that patients and physicians most want answered. I recently wrote about the limitations of the method in studying effectiveness, which is what we care about in real-world situations.
But the randomised controlled trial remains a powerful tool. It's still, perhaps, the best method for conducting explanatory research. In past articles, I have recounted numerous times when hypotheses from observational studies, those based solely on observations of particular groups, have failed to be confirmed by a controlled trial.
Perhaps the greatest strength of the randomised controlled trial is in combating what's known as selection bias. That occurs when groups being studied (intervention and control) are already significantly different after they are "selected" to be in the intervention or not. One of the most elegant examples of why we need such trials came recently in an examination of employer-sponsored wellness programs.
NEW YORK — The gold standard of medical research, the randomised controlled trial, has been taking a bit of a beating lately.
An entire issue of the journal Social Science and Medicine was recently devoted to it, with many articles pointing to shortcomings. Others have argued that randomised controlled trials often can't address the questions that patients and physicians most want answered. I recently wrote about the limitations of the method in studying effectiveness, which is what we care about in real-world situations.
But the randomised controlled trial remains a powerful tool. It's still, perhaps, the best method for conducting explanatory research. In past articles, I have recounted numerous times when hypotheses from observational studies, those based solely on observations of particular groups, have failed to be confirmed by a controlled trial.
Perhaps the greatest strength of the randomised controlled trial is in combating what's known as selection bias. That occurs when groups being studied (intervention and control) are already significantly different after they are "selected" to be in the intervention or not. One of the most elegant examples of why we need such trials came recently in an examination of employer-sponsored wellness programs.